Intro
Chrome on Windows uses Ctrl as its primary modifier. If you're coming from Mac, every Command combination in Chrome becomes a Ctrl combination on Windows, the actions are identical, only the key changes.
Windows also adds F-key shortcuts that don't need a function modifier. F5 reloads the page, F12 opens DevTools, F6 focuses the address bar. These work without holding Fn because on Windows keyboards, F-keys default to their function key behavior rather than media controls.