Global shortcuts. Press C to create a work item, or open the command palette (Cmd+K / Ctrl+K) to run any named command without leaving the keyboard.
Work item navigation and actions. With a work item selected: O opens it, A assigns it to someone, I assigns it to you, M adds a comment. J and K move down and up between rows, N and P move between columns.
List view editing. Tab and the arrow keys move between cells, Home/End jump to the start or end of a row, and Enter confirms an edited value.
Text editor formatting. Inside a description or comment field, Cmd/Ctrl+B, +I, and +U apply bold, italic, and underline, and typing "/" opens quick insert.