F-key behavior on Mac. Excel relies on F-keys for several important operations: editing the active cell, toggling between absolute and relative cell references in formulas, opening the Go To dialog, and inserting a chart. On macOS, F-keys are mapped to system functions (brightness, volume, Mission Control) by default. To use these Excel shortcuts directly, you either hold Fn alongside the F-key, or change the F-key behavior in System Settings → Keyboard to treat F-keys as standard function keys.
For regular Excel users on Mac, changing this setting is worth considering, Excel's F-key shortcuts are used frequently enough that pressing Fn each time becomes a friction point.
Mixed modifier keys. Excel on Mac uses both Command and Ctrl in different parts of its shortcut set, a legacy of the application's history across platforms. Some shortcuts that might be expected to use Command actually use Ctrl on Mac. The table above shows the exact key for each action.
Cell range navigation. Jumping to the last filled cell in a column or row, one of the most-used navigation techniques in large spreadsheets, uses a Command+Arrow combination on Mac. This is a natural Mac-style shortcut and works consistently throughout cell navigation.
Formula confirmation. Excel on Mac has specific shortcuts for confirming a formula in a cell, filling a selection with the same value, and navigating within the formula bar. These follow Command patterns.